Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia

The maintenance of tissue, organ, and organism homeostasis relies on an intricate network players mechanisms that assist in the different forms cell–cell communication. Myocardial infarction, following heart ischemia reperfusion, is associated with profound changes key processes intercellular communication, involving gap junctions, extracellular vesicles, tunneling nanotubes, some which have been implicated communication defects cardiac injury, namely arrhythmogenesis progression into failure. Therefore, emerged as attractive powerful therapeutic targets aimed at preserving a fine-tuned crosstalk between cells order to prevent or repair harmful consequences re-establishing myocardial function.